jashkenas/coffeescript
CoffeeScript is a little language that compiles into JavaScript. Underneath that awkward Java-esque patina, JavaScript has always had a gorgeous heart. CoffeeScript is an attempt to expose the good parts of JavaScript in a simple way.
The golden rule of CoffeeScript is: "It's just JavaScript." The code compiles one-to-one into the equivalent JS, and there is no interpretation at runtime. You can use any existing JavaScript library seamlessly from CoffeeScript (and vice-versa). The compiled output is readable, pretty-printed, and tends to run as fast or faster than the equivalent handwritten JavaScript.